Albany, NY -- (ReleaseWire) -- 07/15/2014 -- CSF, is an abbreviation for Cerebrospinal Fluid, is an essential component of the brain and the central nervous system. Produced by the choroid plexus (Lower arterial part) of the brain, the CSF not only acts as a protection mechanism, but also as a chemical stabilizer, brain buoyancy regulator, toxin clearance system, and pressure maintenance system. It is produced daily and circulated throughout the exterior of the brain (subarachnoid space), such that only 100-160ml is circulated at any given time. The relevance of CSF therefore lies in the diseases that can cause any disruptions in the functionality of the CSF and thereby the function of the brain. This is therefore a growing area of interest, as research is still in process to understand the dynamics of CSF production, regulation and the blood-brain-barrier.
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One of the accepted ways to diagnose the condition and the contents of CSF is by Lumbar puncture. Lumbar puncture (LP) is done at the lower spine region called as lumbar, a surgeon/ doctor/ physician first sterilizes the area and then injects a needle which collects the CSF in a vial. CSF of a healthy individual is usually clear in visibility and water like in composition. Murky or whitish fluid is a sign of infection, generally meningitis, etc. Some scientists believe there exists a relation between Alzheimer’s disease and CSF content, the presence of certain proteins indicates the existence or the possibility for the condition. Besides this, CSF is also used as a route for administration of any drugs in adverse cases or complications, although the risk of increasing cranial pressure is high. CSF is under the radar for many neurotropic and psychedelic drug manufacturers, besides those tending to brain stroke/hemorrhage and neurogenerative disorders. CSF shunt is another area of concern/interest; these shunts are regions where there is passage of the CSF from one region to the other.
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Shunt drains are certain type of devices that help in decreasing the cranial pressure during surgeries and other procedures that may require its assistance, e.g. tumor removal, infection therapy (antibiotics) and hematoma to name a few . Lumbar puncture is nowadays almost extensively used for any differential diagnostic procedures. Hydrocephalus is a majorly diagnosed condition, generally associated with increased cranial pressure.
One of the major factors driving the CSF management market includes the fact that the growing geriatric population in the world shall present a significant market in the coming years. Also the population explosion shall mean that there would be a greater number of individuals having the symptoms of Alzheimer’s and Parkinson’s, to name a few. Patients also prefer minimally invasive surgical procedure hence they are inclined to favor the technology. The factors opposing the growth of CSF market would be the growing concern for the CSF management, the restraints in clinical trials for the development of designs and the high price of the devices.
At present the largest market for CSF devices and procedures remains with the North Americas, this is followed by the European region. The Asia-Pacific region sees the highest growth potential and is expected to displace the European market soon, then after, the North American market. The Asian region has the highest population and hence has the greatest potential. The entry of Asian Players on the global scale shall also prove to be a valuable stimulant to the overall global market. The rest of the world region has Brazil and the Middle-East as its prime market. Africa currently is the smallest market by volume.
Some of the company’s manufacturing devices related to CSF are, Medtronic Becker, Codman EDS, Integra LifeSciences and Liquogaurd Moeller to name a few.
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