Surgical sealants are used after surgery or traumatic injury, as to hold the external and internal tissues. Some of the major surgical sealants based on their composition are collagen-based compounds, fibrin sealant, synthetic sealant, such as cyanoacrylates, and tissue adhesive glues such as hydogels and glutaraldehyde glues. Fibrin sealant also known as fibrin glue is a hemostatic agent. Fibrin glue is the unique adhesion material used in surgeries for closure of wounds. Fibrin glues are mainly extracted from collective plasma and contain different amounts of purified and virally inactivated human proteins. Fibrin glue is composed of two components such as fibrinogen and factor XIII. These concentrated ingredients interact with a solution of thrombin and calcium to form a coagulum. As the thrombin combine with the fibrinogen/factor XIII, a stable clot is formed of a blood protein called fibrin in few seconds, depending on the dilute form of thrombin is used. Some of the characteristics of fibrin glue are high internal bonding strength, high surface adherence strength, enhance tissue regeneration and enhance clot formation. Fibrin glue is mainly used in cardiac surgery, vascular surgery, burn bleeding, pulmonary surgery and lacerations of liver and spleen. It is also used in other surgeries such as neurosurgery, plastic surgery, wound management, general surgery and orthopedic surgeries. Fibrin glue lowers the risks of infection, provides early hemostasis on the treated area and improves cosmesis. It also promotes natural tissue healing. However, small risks of contamination of glue with viruses in human can be one of the disadvantages of fibrin glue. Tisseel, biocol and beriplast are some of the commercially prepared fibrin sealants.