Seattle, WA -- (SBWIRE) -- 10/01/2019 -- Cell-free protein expression is also known cell-free protein synthesis, in vitro translation, cell-free translation or in vitro protein expression. It is a sophisticated, rapid, and effective technique for synthesizing proteins in cell lysates instead of using cultured cells. Cell-free protein expression extracts the desired cells with the help of translation machineries. It can be done by using various types of mammalian cells, plants, bacteria, and insect cells over traditional in vivo method. For instance, cell-free protein expression system works individually and is free of any cellular context. Due to these benefits, it is ideal for high-throughput screening of mutagenesis. Moreover, the whole mechanism of cell-free expression system offers better environment for manufacturing of membrane proteins, toxic proteins, and proteins that can undergo degradation.

Moreover, pharmaceutical and biotechnological sectors use these tools for research and developmental activities and also for genomics and proteomics. Hence, it is a major factor driving growth of the global cell-free protein expression market during the forecast period.

The global cell-free protein expression market size was valued at US$ 177.1 million in 2017, and is expected to register a CAGR of 6.2% during the forecast period (2018 – 2026).

Robust research and development activities is expected to drive growth of the global cell-free protein expression market

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Growing research and development activities in the sector of genomics and proteomic coupled with increasing prevalence of infectious diseases and cancer are expected to drive growth of global cell-free protein expression market during the forecast period. For instance, according to 2012, EU Industrial R&D Investment Scoreboard, the pharmaceutical and biotechnology sectors accounted for 17.7% of research and development expenditure in the world. Moreover, growing prevalence of infectious disease and cancer cases across the world has led to high adoption of cell samples for research and development of drugs. This, in turn, is expected to support growth of the global cell-free protein expression market. For instance, according to GLOBOCAN Estimates, 2012, around 850,000 new cancer cases were diagnosed in Africa, while almost 600,000 deaths caused due to malignant disease. According to the same source, the number of cancer cases are expected to reach 1,056,000 by 2020. Furthermore, according to the World Health Organization (WHO), in 2012, around 3,319 deaths occurred due to the infectious and parasitic disease infection, in Sub-Saharan Africa region. According to the same source, in 2014, Ebola accounted for around 8,000 deaths in this region.

High cost associated with protein expression for certain species is expected to hinder the market growth

High cost and low yield of protein from certain species along with lack of eukaryotic co- and post-translational modifications are likely to hamper growth of global cell-free protein expression market during the forecast period. For instance, cell-free system based on E. coli and wheat germ extracts have some drawbacks to produce human proteins with post translation modifications (PTMs), which is restraining growth of the global cell-free protein expression market growth.

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Global Cell-free Protein Expression Market- Regional Analysis
Global cell-free protein expression market is segmented into six major regions- North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. Increasing demand for precision medicine coupled with increasing cell-based research in North America is expected to boost cell-free protein expression market growth in the region. For instance, in 2015. Precision Medicine Initiative was launched in the U.S. to transform disease treatment, which includes cancer and other chronic diseases. Precision medicine offers custom-made treatment for individual patient as per the genetic makeup of the person. Moreover, increasing importance on genomic and proteomics activities Germany, U.K., France, and Switzerland are expected to drive growth of the Europe cell-free protein expression market. For instance, in 2018, UK Biobank started an initiative to sequence the full genomes of 50,000 UK Biobank volunteer participants. This initiative received funding of US$ 39.8 million from Medical Research Council. The investment accelerated research and development activities for numerous diseases related to premature death and disability. Asia Pacific is expected to register significant growth in the market, owing to increasing research laboratories, pharmaceutical companies, and contract research organizations. For instance, in 2017, China's expenditure on research and development increased by 11.6% year-on-year to US$ 280 Bn.

Global Cell-free Protein Expression Market- Competitive Landscape
Increasing investments and initiatives by key players in the market is expected to drive growth of the global cell-free protein expression market over the forecast period. For instance, in September 2017, iBio, Inc. with its subsidiary iBio CDMO LLC, a contract development and manufacturing organization (CDMO), entered into a collaboration with TheoremDx, Inc. to develop proteins for rapid diagnostic testing products. The collaboration aimed to offer plant proteins through robust development and manufacturing in the U.S. and other economies. IBio is expected to provide an expression system to TheoremDx, which allows establishment of new diagnostics through cGMP scale-up production. Both iBio and TheoremDx are specifically focusing on development of rapid diagnostic tests, which can help in identifying and distinguishing neglected tropical diseases such as Zika, West Nile, Dengue, and Chikungunya. This collaboration is a major strategic step for advancement of rapid detection test internationally.

Key players operating in global cell-free protein expression market include iBio CDMO LLC, Thermo Fisher Scientific Inc., Takara Bio, Inc., New England Biolabs, Promega Corporation, CellFree Sciences Co., Ltd., Biotechrabbit GmbH, Bioneer Corporation, Cube Biotech GmbH, Jena Bioscience GmbH, and GeneCopoeia, Inc.

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