Boston, MA -- (ReleaseWire) -- 06/03/2013 -- GlobalData has released its new PharmaPoint Drug Evaluation report, "Romosozumab (Osteoporosis) - Forecast and Market Analysis to 2022". Despite its maturity, the osteoporosis market is expected to undergo substantial change between 2012 and 2022. Most importantly, the 'gold-standard' bisphosphonates will lose patent protection by end-of-year 2013, flooding the marketplace with less expensive generic versions of these physician-preferred medications. Additionally, Eli Lilly's blockbuster Evista, the only available SERM in the US, will lose patent protection in 2014, flooding the market with yet more affordable generic options. Also during the forecast period covered by this report, osteoporosis drug development research will lead to the launches of a wave of novel anabolic drugs with greater efficacy and safety, causing a major market shift away from anti-resorptive drugs. The number of companies vying for patient share will shrink by as much as 50%, as established players exit the market or acquire smaller players. Lastly, the aging of the population in developed markets will result in a larger patient pool.
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These changes in the osteoporosis market will be reflected in the slow growth during the forecast period, with the market growing from $6 billion to $8 billion in 2011 USD at a CAGR of 3%.
Romosozumab (previously referred to as AMG-785) is an anti-sclerostin mAb being developed by Amgen and UCB. It is an anabolic treatment rather than an antiresorptive treatment, and it works by inhibiting sclerostin, a protein secreted by osteocytes that downregulates osteoblast-mediated bone formation (Padhi et al., 2010). By blocking sclerostin, romosozumab stimulates bone formation, resulting in greater bone density (Padhi et al., 2010).
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- Overview of Osteoporosis, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Romosozumab including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Romosozumab for the top seven countries from 2012 to 2022.
- Sales information covered for the US, France, Germany, Italy, Spain, the UK and Japan
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- Stay ahead of the competition by understanding the changing competitive landscape for Osteoporosis
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- Make more informed business decisions from insightful and in-depth analysis of Romosozumab performance
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