Colorectal cancer is a malignant tumor on the inner wall of the large intestine. This is due to the abnormal growth of cells which have the ability to invade or spread to other parts of the body. The common causes of colorectal cancer are inflammatory bowel disease and genetic inheritance. The common symptoms of colorectal cancer include fatigue, diarrhea or constipation, shortness of breath, weakness, change in bowel habits, red or dark blood in stool, cramps, narrow stools, weight loss, abdominal pain, and bloating. These symptoms may develop several years after the formation of the tumor. Various stages for colorectal cancer are: stage 0, cancer in very early stages present in the innermost layer of the intestine; stage I, cancer present in the inner layers of colon; stage II, cancer spreads through muscle wall of colon; stage III, cancer spreads to lymph nodes, stage IV, cancer spreads to other organs. Some of the drugs in the pipeline for colorectal cancer therapeutics are Lonsurf, CYRAMZA (ramucirumab), TS-1/Teysuno, CPP-1X (eflornithine hydrochloride), MelCancerVac, Xilonix, and Nintedanib. There are various medications such as chemotherapy drugs, immunotherapy, and leucovorin (chemoprotectant) that can be used to treat colorectal cancer. Chemotherapy drugs for the treatment of colorectal cancer include antimetabolities such as fluorouracil and capecitabine. Monoclonal antibodies used in immunotherapy as part of the treatment of colorectal cancer are bevacizumab, cetuximab, and panitumumab.